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What Is Wellbutrin and How Does It Work?

Wellbutrin is the brand name for Bupropion, a norepinephrine-dopamine reuptake inhibitor 

(NDRI). Unlike SSRIs and SNRIs, which influence serotonin levels, Wellbutrin targets 

dopamine and norepinephrine—key neurotransmitters involved in motivation, focus, and 

energy.

It’s commonly prescribed in three main formulations:

Wellbutrin IR (Immediate Release)

Wellbutrin SR (Sustained Release)

Wellbutrin XL (Extended Release)

Each version has a different absorption rate and dosing frequency. The XL version is 

generally taken once daily and offers a smoother delivery, often making it the preferred 

choice for long-term management of depression or seasonal affective disorder.

Because Wellbutrin’s action differs from that of serotonin-based antidepressants, 

tapering it off follows a different logic. Patients who stop abruptly may not always 

experience the same type of discontinuation syndrome seen with SSRIs, but they can still

face significant side effects.